Skin: Hemidesmus indicus cools and reduces heat and inflammation from the skin.  It is an effective herb to cure eczema, erysipelas, psoriasis, urticaria from heat and aggravated pitta. It purifies the blood, stops itching and reduces suppuration. The root powder is used in treating STDs that are damp and hot.
Urinary: It is very useful in urinary infections with dark red, painful urination, cystitis, urethritis, kidney infections and prostatitis.

Nerves: As it is purificator in nature, it is useful in disturbed, angry or irritated emotions and maintains the equilibrium of the mind. It reduces vata indirectly by calming the fire generated in pitta.